ABSTRACT
BACKGROUND:Functional graded biomaterials promote the development of human hard tissue replacement.OBJECTIVE:To review the research progress of functional graded biomaterials in human hard tissue replacement.METHODS:The first author retrieved the PubMed and CNKI databases for relevant articles published from January 2010 to April 2017 using the keywords of "functional graded biomaterial,hard tissue replacement implants,preparation methods,performance evaluation,dental implants,osseous tissue" in English and Chinese,respectively.RESULTS AND CONCLUSION:Functional graded biomaterials refer to a kind of heterogeneous composite materials with controllable and programmable gradient properties on account of continuous or quasi-continuous changes in the structure and chemical composition.Hydroxyapatite is the primary choice for the material surface.Serving as an emerging biomaterial,the functional graded biomaterial has unique structure mechanism and excellent properties.It gives full play to the performance advantages of each component and reduces internal stress interface between components.Therefore,the functional graded biomaterial will be an issue of concern in the future because of the optimization of its design,preparation and performance.